SORANIB-200

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Manufacturer : CIPLA
Generic Name : SORANIB-200
Packing Size : 30 TABLETS

SORANIB IS EQUIVALENT AS NEXAVAR, a kinase inhibitor, is the tosylate salt of sorafenib.

Sorafenib tosylate has the chemical name 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}p...

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1X 30 TABLETS $100.00 $3.33
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2X30 TABLETS $190.00 $3.17
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4X30 TABLETS $370.00 $3.08
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6X30 TABLETS $560.00 $3.11
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10X30 TABLETS $900.00 $3.00
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Description

Description


SORANIB IS EQUIVALENT AS NEXAVAR, a kinase inhibitor, is the tosylate salt of sorafenib.



Sorafenib tosylate has the chemical name 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)N2methylpyridine-2-carboxamide 4-methylbenzenesulfonate and its structural formula is:


Sorafenib tosylate is a white to yellowish or brownish solid with a molecular formula of C21H16ClF3N4O3 x C7H8O3S and a molecular weight of 637.0 g/mole. Sorafenib tosylate is practically insoluble in aqueous media, slightly soluble in ethanol and soluble in PEG 400.


Each red, round NEXAVAR film-coated tablet contains sorafenib tosylate (274 mg) equivalent to 200 mg of sorafenib and the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, hypromellose, sodium lauryl sulphate, magnesium stearate, polyethylene glycol, titanium dioxide and ferric oxide red.

Doses

Doses


The recommended daily dose of NEXAVAR is 400 mg (2 x 200 mg tablets) taken twice daily without food (at least 1 hour before or 2 hours after a meal). Treatment should continue until the patient is no longer clinically benefiting from therapy or until unacceptable toxicity occurs.



Management of suspected adverse drug reactions may require temporary interruption and/or dose reduction of NEXAVAR. When dose reduction is necessary, the NEXAVAR dose may be reduced to 400 mg once daily. If additional dose reduction is required, NEXAVAR may be reduced to a single 400 mg dose every other day [see WARNINGS AND PRECAUTIONS].



Suggested dose modifications for skin toxicity are outlined in Table 1.



Table 1: Suggested Dose Modifications for Skin Toxicity

Warning & Precautions

Warning & Precautions


Stop using sorafenib and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.



Call your doctor at once if you have any of these serious side effects:



  • rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;

  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

  • easy bruising, unusual bleeding;

Side Effects

Side Effects
Acne, dry skin, nausea, diarrhea, patchy hair loss/thinning, loss of appetite, dry mouth, hoarseness, or tiredness may occur. If these effects persist or worsen, notify your doctor or pharmacist promptly.


Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Storage

Storage

  • Store NEXAVAR tablets at room temperature between 59 to 86° F (15 to 30° C).

  • Store NEXAVAR tablets in a dry place.

  • Keep NEXAVAR and all medicines out of the reach of children.

Disclaimer

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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